SRT3+T2-15 Slow Release T3+T2 (15/15mcg)
New 2026 Formulation
Updated slow-release matrix for improved bioavailability
HPMC + MCC Only · 4-8 Hour Release
Two-excipient formulation, minimal allergen and MCAS-trigger profile
1:1 T3+T2 · Mitochondrial Co-Activator
Bypasses both the T4→T3 and T3→T2 conversion bottlenecks
Sustained-release combination of T3 (liothyronine) and 3,5-T2 (3,5-diiodo-L-thyronine) at 15 mcg each in a 1:1 ratio per capsule. HPMC slow-release matrix extends release over 4-8 hours. Used in research on T3-protocol plateau correction, mitochondrial co-activation, and the T3->T2 conversion bottleneck.
Molecular Characteristics
Minimalist Excipient Profile
SRT3 uses only two excipients: hydroxypropyl methylcellulose (HPMC) and microcrystalline cellulose (MCC). HPMC provides the matrix that extends T3 release over a 4-8 hour window; MCC serves as the inert filler. No dyes, fillers, gums, lactose, gluten, or surfactants commonly found in compounded T3 formulations. This minimal profile is intended for research subjects with sensitivities to common excipients (MCAS, mast cell, or multi-allergen research models).
Why T2?
Wilson's Protocol solved the T4→T3 conversion problem - the well-known bottleneck where deiodinase dysfunction in chronic illness leaves cells unable to make enough active T3 from circulating T4. What it doesn't address: the body still has to perform a second conversion from T3 to T2 to deliver the mitochondrial effect.
The same deiodinase enzymes that handle T4→T3 also produce T2 from T3 (DIO1 is the major contributor). The same dysfunction that blocks the first step can impair the second. Patients on a full T3 protocol who still hit a metabolic plateau often have plenty of T3 at the receptor but insufficient T2 reaching the mitochondria.
3,5-T2 binds directly to cytochrome c oxidase inside the mitochondria - the molecular target where actual metabolic-rate elevation happens. Supplying T2 alongside T3 in a 1:1 ratio means both bottlenecks are bypassed simultaneously: the receptor gets the active T3 it needs, and the mitochondria get the T2 they need.
For the deep dive, see The T3→T2 Conversion Problem and the complete 3,5-T2 research guide.
Research Use Only
For laboratory research use only. Not for human or animal consumption, diagnostic, or therapeutic use.
Discreet Shipping
Discreet plain-label packaging.
Questions about customs in your country? Reach out to your Chronic Illness Store representative - or if you've lost contact, email us directly.